Primary Cilia in Brain Development and Diseases
نویسندگان
چکیده
منابع مشابه
Primary cilia and forebrain development
With a microtubule-based axoneme supporting its plasma membrane-ensheathed projection from the basal body of almost all cell types in the human body, and present in only one copy per cell, the primary cilium can be considered an organelle sui generis. Although it was first observed and recorded in histological studies from the late 19th century, the tiny structure was essentially forgotten for ...
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Primary cilia were the largely neglected nonmotile counterparts of their better-known cousin, the motile cilia. For years these nonmotile cilia were considered evolutionary remnants of little consequence to cellular function. Fast forward 10 years and we now recognize primary cilia as key integrators of extracellular ligand-based signaling and cellular polarity, which regulate neuronal cell fat...
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In recent decades, cilia have moved from relative obscurity to a position of importance for understanding multiple complex human diseases. Now termed the ciliopathies, these diseases inflict devastating effects on millions of people worldwide. In this review, written primarily for teachers and students who may not yet be aware of the recent exciting developments in this field, we provide a gene...
متن کاملCiliopathies: Primary Cilia and Signaling Pathways in Mammalian Development
1.1 Ciliopathies, an emerging class of human genetic diseases The physiological role of motile cilia or flagella in cell locomotion, sexual reproduction and fluid movements is well known. In 1898, the Swiss anatomist KW Zimmerman first described cilia on the surface of mammalian cells, for which he suggested a sensory role. His findings were largely ignored until the late 1960s, when Wheatley, ...
متن کاملPrimary cilia
The primary cilium was first so named by Sergei Sorokin in 1968.[1] Since the discovery of primary cilium in 1898 by Zimmerman, three major hypotheses for their function have been put forth. The first is that primary cilia are vestigial organelles inherited from an ancestor whose cells had motile cilia and now are of no purpose in multicellular organisms. The second is that they are involved in...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2018
ISSN: 0002-9440
DOI: 10.1016/j.ajpath.2017.08.031